The role of cancer-associated fibroblasts in bladder cancer progression
Long Huang, Qun Xie, Jian Deng, Wen-Fei Wei
Abstract
Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.
Topics & Concepts
Cancer-Associated FibroblastsStromal cellBladder cancerTumor microenvironmentMetastasisCancer researchTumor progressionCancerCancer cellMedicineBiologyOncologyTumor cellsInternal medicineEpigenetics and DNA MethylationCancer Cells and MetastasisBladder and Urothelial Cancer Treatments