FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation
Xingyan Xu, Xuefen Zhuang, Haowei Yu, Ping Li, Xiaosa Li, Hui‐Ping Lin, Jian‐peng Teoh, Yi-Wen Chen, Yuanlan Yang, Cheng Yang, Weiyu Chen, Xiaodong Fu
Abstract
These findings indicated that FSH induces EMT progression and ovarian cancer metastasis via CREB/ALKBH5/Snail pathway. Thus, this study provided new insight into the therapeutic strategy of ovarian cancer patients with high level of FSH.
Topics & Concepts
Ovarian cancerCancer researchMetastasisBiologyCarcinogenesisImmunohistochemistryEpithelial–mesenchymal transitionCancerInternal medicineMedicineImmunologyGeneticsRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation