BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease
Thomas G. Martin, Sara Tawfik, Christine S. Moravec, Toni R. Pak, Jonathan A. Kirk
Abstract
Myofilament BAG3 expression decreases in male patients with nonischemic DCM but is preserved in female patients with DCM. BAG3 expression in the human heart is tightly linked to HSF-1 expression and nuclear translocation. HSF-1 localizes to the sarcomere Z-disc in the human heart. HSF-1 expression in the myofilament fraction decreases in male patients with DCM and positively correlates with myofilament BAG3.
Topics & Concepts
MyofilamentSarcomereInternal medicineCardiologyBAG3Cell biologyBiologyMedicineAnatomyEndocrinologyMyocyteGeneticsAutophagyApoptosisHeat shock proteins researchCardiovascular Effects of ExerciseCardiomyopathy and Myosin Studies