Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development
Frank Pui-Ling Lai, Zhixin Li, Tingwen Zhou, Adrian On-Wah Leung, Sin-Ting Lau, Kathy Nga-Chu Lui, William Yu-Ming Wong, Pak C. Sham, Chi‐chung Hui, Esw Ngan
Abstract
mutants. In summary, Hedgehog signal, via Kif7-Gli-Ezh2, controls the timely expressions of the core genes to mediate the differentiation of ENCCs.
Topics & Concepts
Neural crestCell biologyEZH2BiologyEnteric nervous systemNeuroscienceCrestMedicineGeneticsPhysicsGene expressionGeneQuantum mechanicsEmbryoCongenital gastrointestinal and neural anomaliesCongenital Anomalies and Fetal SurgeryPediatric Hepatobiliary Diseases and Treatments