Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit
Simona Presente, Christine Bonnal, Anne‐Cécile Normand, Y. Gaudonnet, Arnaud Fekkar, Jean‐François Timsit, Solen Kernéis
Abstract
We report the first identification of a fluconazole-resistant Candida parapsilosis (FR- Cp ) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR- Cp isolates belonged to the same clone.
Topics & Concepts
Candida parapsilosisFluconazoleGenotypingIntensive care unitOutbreakclone (Java method)BiologyMicrobiologyIntensive careVirologyGenotypeMedicineAntifungalInternal medicineIntensive care medicineGeneticsGeneAntifungal resistance and susceptibilityFungal Infections and StudiesInfections and bacterial resistance