Identification and evaluation of a novel PARP1 inhibitor for the treatment of triple-negative breast cancer
Rong Gong, Zhong-Ye Ma, LinHao He, Shilong Jiang, Dongsheng Cao, Yan Cheng
Topics & Concepts
OlaparibTriple-negative breast cancerPARP1Cancer researchSynthetic lethalityPARP inhibitorBreast cancerCancerCisplatinDNA damageChemistryApoptosisCancer cellBiologyDNA repairMedicineChemotherapyPoly ADP ribose polymeraseInternal medicineDNABiochemistryPolymerasePARP inhibition in cancer therapyDNA Repair MechanismsCell death mechanisms and regulation