Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer
Lin Hao, Kun Pang, Hui Pang, Junjie Zhang, Zhiguo Zhang, Houguang He, Rongsheng Zhou, Zhenduo Shi, Conghui Han
Abstract
. We also found that ETV4 bound directly to the promoter region of P3H4 and activated its transcription. Furthermore, overexpression of ETV4 rescued the inhibition of proliferation and invasion induced by PH4 silencing. ETV4 was significantly overexpressed in the BC tissues. In conclusion, P3H4 functioned an oncogene role in BC progression, and ETV4 bound directly to the P3H4 promoter region to regulate its transcription.
Topics & Concepts
Gene knockdownCancer researchCancerBladder cancerMedicineBiologyInternal medicineApoptosisGeneticsBladder and Urothelial Cancer TreatmentsSulfur Compounds in BiologyCancer, Lipids, and Metabolism