SIRT6-mediated Runx2 downregulation inhibits osteogenic differentiation of human aortic valve interstitial cells in calcific aortic valve disease
Jiaqi Xiong, Wenfeng Lin, Chunze Yuan, Jinhui Bian, Yifei Diao, Xinyang Xu, Buqing Ni, Hui Zhang, Yongfeng Shao
Topics & Concepts
RUNX2CalcificationAortic valveDownregulation and upregulationInterstitial cellSIRT6Cancer researchPathogenesisMedicineInternal medicineChemistryAcetylationOsteoblastIn vitroBiochemistryGeneSirtuinSirtuins and Resveratrol in MedicineCalpain Protease Function and RegulationAutophagy in Disease and Therapy