Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
Karin Gustafsson, Sergey Isaev, Kamdin Mirsanaye, Johanna Hofmann, Kameron Kooshesh, Ninib Baryawno, Anna Kiem, Nicolas Sévère, Ting Zhao, Elizabeth W. Scadden, Joel A. Spencer, Christian Burns, Kumaran Akilan, Nikolaos Barkas, Hayalneh Gessessew, Konstantinos D. Kokkaliaris, Charles P. Lin, Peter V. Kharchenko, David T. Scadden
Topics & Concepts
BiologyMesenchymal stem cellNeogenesisT cellCell biologyCCL19Immune systemImmunologyLymphopoiesisStem cellRegeneration (biology)Progenitor cellHaematopoiesisNicheThymectomyChemokineProgenitorCellAcquired immune systemHematopoietic stem cellImmunityImmune toleranceT lymphocyteCCL5Cellular differentiationTransplantationRegulatory T cellAdoptive cell transferStromal cellB cellCell typeCD28Cell therapyClinical uses of mesenchymal stem cellsT-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationIL-33, ST2, and ILC Pathways