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Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment

Di Wu, Yehao Luo, Tong Li, Xinyi Zhao, Ting Lv, Gang Fang, P. Ou, Hongyi Li, Xiaofan Luo, An Huang, Yuzhou Pang

2022Frontiers in Immunology237 citationsDOIOpen Access PDF

Abstract

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

Topics & Concepts

Rheumatoid arthritisMedicinePathogenesisIncidence (geometry)DiseaseArthritisAutoimmune diseaseImmunologyIntensive care medicineDermatologyPathologyOpticsPhysicsRheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus ResearchChronic Lymphocytic Leukemia Research