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Increased levels of circulating oxidized mitochondrial DNA contribute to chronic inflammation in metabolic syndrome, and MitoQ-based antioxidant therapy alleviates this DNA-induced inflammation

Wei Ye, Chaowei Wen, Aibing Zeng, Xingzhong Hu

2022Molecular and Cellular Endocrinology16 citationsDOI

Topics & Concepts

InflammationTLR9Mitochondrial DNAPeripheral blood mononuclear cellOxidative stressMitochondrial ROSAntioxidantMolecular biologyPharmacologyMitochondrionMedicineBiologyImmunologyInternal medicineEndocrinologyChemistryIn vitroBiochemistryGene expressionGeneDNA methylationMitochondrial Function and PathologyATP Synthase and ATPases ResearchInflammasome and immune disorders
Increased levels of circulating oxidized mitochondrial DNA contribute to chronic inflammation in metabolic syndrome, and MitoQ-based antioxidant therapy alleviates this DNA-induced inflammation | Litcius