The selection of highly specific and selective aptamers using modified SELEX and their use in process analytical techniques for Lucentis bioproduction
Tanu Bhardwaj, Anurag S. Rathore, Sandeep Kumar Jha
Abstract
a standard HPLC method, and better correlation was found between the HPLC and aptamer 1 results than the aptamer 25 results; hence, aptamer 1 can be further analyzed and tested for use in affinity column chromatography and detection-kit/chip-based PAT for Lucentis bioproduction.
Topics & Concepts
BioproductionAptamerSystematic evolution of ligands by exponential enrichmentSelection (genetic algorithm)Process (computing)Computer scienceNanotechnologyChemistryMaterials scienceBiologyArtificial intelligenceOperating systemRNABiochemistryGeneGeneticsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionInnovative Microfluidic and Catalytic Techniques Innovation