LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood–brain barrier
Dan Liu, Mingyang Zhu, Yi Lin, Mengmeng Li, Ruolan Huang, Yang Liu, Yanling Song, Yong Diao, Chaoyong Yang
Abstract
model system uses a miniaturized chip to enable high-throughput investigations of AAV crossing efficiency in the BBB, and provides strong initial evidence that human LY6E mediates AAV-PHP.eB crossing the BBB.
Topics & Concepts
Blood–brain barrierTree traversalBiophysicsBiologyNeuroscienceComputer scienceCentral nervous systemProgramming languageBarrier Structure and Function StudiesSingle-cell and spatial transcriptomicsVirus-based gene therapy research