MUTYH: Not just polyposis
Maria Cristina Curia, Teresa Catalano, Gitana María Aceto
Abstract
SNPs have been associated with lung, hepatocellular and cervical cancer risk. An additional role of MUTYH seems to contribute to the prevention of numerous other disorders with an inflammatory/degenerative basis, including neurological and ocular diseases. Finally, it is interesting to note that MUTYH could be a new therapeutic target and future studies will shed light on its specific functions in the prevention of diseases and in the improvement of the chemo-sensitivity of cancer cells.
Topics & Concepts
MUTYHBase excision repairMedicineColorectal cancerCancer researchDNA mismatch repairDNA glycosylaseDNA repairCancerDNA damageBioinformaticsGeneticsGeneBiologyDNAInternal medicineGenetic factors in colorectal cancerDNA Repair MechanismsCancer Genomics and Diagnostics