An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children
Angela Klain, Giulio Dinardo, Alessandra Salvatori, Cristiana Indolfi, Marcella Contieri, Giulia Brindisi, Fabio Decimo, Anna Maria Zicari, Michele Miraglia del Giudice
Abstract
The prevalence of non-allergic asthma in childhood is low, peaking in late adulthood. It is triggered by factors other than allergens, like cold and dry air, respiratory infections, hormonal changes, smoke and air pollution. In the literature, there are few studies that describe non-allergic asthma in pediatric age. Even though it is a less common disorder in kids, it is crucial to identify the causes in order to keep asthma under control, particularly in patients not responding to conventional treatments. In this review, we discuss non-IgE-mediated forms of asthma, collecting the latest research on etiopathogenesis and treatment.