CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis–angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF
Houlin Ji, Xu Cui, Yang Yang, Xiaoxiao Zhou
Abstract
using a cortical bone defect model. We found that hsa_circ_0006215 promoted bone defect repair. Overall, our results showed that hsa_circ_0006215 has an important function in osteogenesis and could be a novel target for treating senile OP.
Topics & Concepts
RUNX2AngiogenesisVEGF receptorsCell biologyChemistryCancer researchBiologyTranscription factorBiochemistryGeneCircular RNAs in diseasesMicroRNA in disease regulationBiomarkers in Disease Mechanisms