A New Insight into the Synthesis and Biological Activities of Pyrazolebased Derivatives
Satbir Mor, Mohini Khatri, Ravinder Punia, Savita Nagoria, Suchita Sindhu
Abstract
Abstract: The aim of this review is to collate literature work reported by researchers (from 1994 to 2021) to provide an overview of the available methodologies for the synthesis and diverse pharmacological activities exhibited by pyrazole based molecules. This review highlights recent reports on various routes of synthesis and potential biological evaluation studies viz. anticancer, AT (II) inhibitory, anti-inflammatory activities, HIV-1-RT inhibitory, antihypertensive, herbicidal, antitubercular, insecticidal, antiviral, antimicrobial and COX-2 inhibitory activity, etc. of pyrazole derivatives and also presents recent efforts made on this heterocyclic moiety.
Topics & Concepts
PyrazoleMoietyCombinatorial chemistryAntimicrobialChemistryBiological activityHuman immunodeficiency virus (HIV)PharmacologyComputational biologyBiologyStereochemistryBiochemistryOrganic chemistryIn vitroVirologyPhosphodiesterase function and regulationSynthesis and biological activityComputational Drug Discovery Methods