Early Onset of TNFα-Driven Arthritis, Auto-inflammation, and Progressive Loss of Vision in a Patient with ALPK1 Mutation
J Hecker, Marilena Letizia, Britt-Sabina Loescher, Britta Siegmund, Carl Weidinger
Abstract
With great interest, we have read the research letter by Jamilloux et al. recently reporting three cases of patients with auto-inflammation and concomitant ectodermal dysplasia and progressive loss of vision due to mutations in the -kinase 1 (ALPK1) gene
Topics & Concepts
InflammationMedicineMedical microbiologyArthritisMutationTumor necrosis factor alphaImmunologyBiologyGeneticsGeneInflammasome and immune disordersSystemic Lupus Erythematosus Researchinterferon and immune responses