The ESX-1 Virulence Factors Downregulate miR-147-3p in Mycobacterium marinum-Infected Macrophages
Xiaoshu Zuo, Lin Wang, Yanqing Bao, Jianjun Sun
Abstract
As important virulence factors of Mycobacterium tuberculosis , EsxA and EsxB not only play a role in phagosome rupture and M. tuberculosis cytosolic translocation but also function as modulators of host immune responses by modulating numerous microRNAs (miRNAs). Recently, we have found that mycobacterial infection downregulated miR-148a-3p (now termed miR-148) in macrophages in an ESX-1-dependent manner. The upregulation of miR-148 reduced mycobacterial intracellular survival.
Topics & Concepts
Mycobacterium marinumVirulenceBiologyMicrobiologyMycobacterium tuberculosisPhagosomeDownregulation and upregulationMycobacteriumMacrophageIntracellularImmune systemTuberculosismicroRNAPhagocytosisImmunologyCell biologyBacteriaGeneGeneticsIn vitroMedicinePathologyTuberculosis Research and EpidemiologyMicroRNA in disease regulationRNA modifications and cancer