Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
Adrián E. Morelli, Tina L. Sumpter, Darling Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Adriana T. Larregina
Abstract
-dependent signaling that sustains the survival of activated T cells and helper 1 (Th1) and Th17 bias. In a model of contact dermatitis, mice with T cells deficient in NK1R or its agonists exhibit impaired cellular immunity, due to high mortality of activated T cells. We demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Topics & Concepts
Cell biologyReceptorG protein-coupled receptorT-cell receptorImmunological synapseT cellBiologySignal transductionSubstance PImmune systemNeuropeptideChemistryImmunologyBiochemistryNeuropeptides and Animal PhysiologyT-cell and B-cell ImmunologyImmune Cell Function and Interaction