Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: <i>In Silico</i> and <i>In Vitro</i> Studies
Amgad M. Rabie, Mohnad Abdalla
Abstract
data supported these biochemical findings, suggesting that riboprine and forodesine molecules and their expected active TP metabolites strongly hit the key catalytic pockets of the SARS-CoV-2 RdRp's and ExoN's main active sites. In brief, the current important results of this comprehensive study revealed the interesting repurposing potentials of, mainly, the two bioactive nucleosides forodesine and riboprine and their TP nucleotides to effectively shut down the polymerase/exoribonuclease-RNA nucleotide interactions of SARS-CoV-2 and consequently treat COVID-19 infections.
Topics & Concepts
NucleotideIn silicoDrug repositioningVirologyRNA polymeraseCoronavirusIn vitroBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ChemistryRNACoronavirus disease 2019 (COVID-19)Molecular biologyBiochemistryDrugMedicinePharmacologyGeneDiseasePathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testing