Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC
Lydia Boike, Alexander G. Cioffi, Felix C. Majewski, Jennifer Co, Nathaniel J. Henning, Michael D. Jones, Gang Liu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Topics & Concepts
CysteineCovalent bondLigand (biochemistry)Intrinsically disordered proteinsChemistryComputational biologyBiophysicsBiochemistryBiologyReceptorOrganic chemistryEnzymeClick Chemistry and ApplicationsChemical Synthesis and AnalysisProtein Degradation and Inhibitors