Enhanced delivery of melatonin loaded nanostructured lipid carriers during<i>in vitro</i>fertilization: NLC formulation, optimization and IVF efficacy
Fatemeh Noori Siahdasht, Nafiseh Farhadian, Mohammad Hossein Karimi, Leili Hafizi
Abstract
environment exhibits a biphasic domain including burst release in the first 2 hours and the controlled release in 48 h 92% of the drug is released from nanoparticles in 48 hours, but the same amount of hormone is released from the marketed drug suspension during 2 hours. Results of IVF experiments reveal that the nanostructured form has a positive effect on all IVF parameters compared to the free form of the hormone. In addition, using the hormone nanostructured form can reduce the dosage of the melatonin free form with the same efficacy in the IVF environment. Finally, the nanostructured form of melatonin based on NLC nanostructure can be a good candidate for application in IVF media.