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Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

Wesam Ali, Gabriella Spengler, Annamária Kincses, Márta Nové, Cecilia Battistelli, Gniewomir Latacz, Małgorzata Starek, Monika Dąbrowska, Ewelina Honkisz-Orzechowska, Annalisa Romanelli, Manuela Monica Rasile, Ewa Szymańska, Claus Jacob, Clemens Zwergel, Jadwiga Handzlik

2020European Journal of Medicinal Chemistry45 citationsDOIOpen Access PDF

Topics & Concepts

EffluxChemistryCancer cellMultiple drug resistanceCytotoxic T cellPharmacologyDoxorubicinCell growthP-glycoproteinATP-binding cassette transporterCancerIn vitroCancer researchBiochemistryTransporterBiologyChemotherapyGeneticsGeneAntibioticsDrug Transport and Resistance MechanismsSynthesis and Biological EvaluationMetal complexes synthesis and properties
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma | Litcius