The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation
Tao Wang, Jinhua Wu, Wei Dong, Mengwen Wang, Xiaodan Zhong, Wenjun Zhang, Lei Dai, Yang Xie, Yujian Liu, Xingwei He, Wanjun Liu, Thati Madhusudhan, Hesong Zeng, Hongjie Wang
Abstract
The current study identifies previously unknown function of MEK/ERK pathway in regulation of ER-stress in DCM. U0126 could be a therapeutic target for the treatment of DCM.
Topics & Concepts
Diabetic cardiomyopathyUnfolded protein responseStreptozotocinMedicineCardiac function curveDiabetes mellitusInternal medicineEndoplasmic reticulumEndocrinologyPharmacologyCardiomyopathyHeart failureCancer researchBiologyCell biologyEndoplasmic Reticulum Stress and DiseaseCardiovascular Function and Risk FactorsAutophagy in Disease and Therapy