Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury <i>via</i> cysteine
Xiaoyan Lu, Nannan Wang, Yuanfang Tao, Jiamin Wang, Xin Ji, Jinying Liu, Weili Zhao, Jian Zhang
Abstract
Herein, by optimizing phenyl selenide-based BODIPYs, BDP-Se-MOS was obtained, which possessed resistance to ROS and could selectively detect Cys. BDP-Se-MOS could not only discriminate between normal and cancer cells, but also image Cys levels in tumor-bearing mice in real time as well as image the fluctuations of Cys levels in an APAP-induced DILI model.
Topics & Concepts
SelenideFluorescenceChemistryCysteineLiver injuryDrugLiver cancerBODIPYCancer researchCancerCombinatorial chemistryPhotochemistryBiophysicsBiochemistryPharmacologySeleniumBiologyMedicineInternal medicineOrganic chemistryEnzymeOpticsPhysicsSulfur Compounds in BiologyLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics