Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection
Lulu Cao, Zhiqiang Cui, Dongxiang Zhang, Yikun Li, Xiaoyan Gao, Rong Shang, Xin‐Dong Jiang, Jianjun Du, Xiaohong Sun
Abstract
Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY ( JLD ) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J -aggregation packing mode. Self-assembled JLD -nanoparticles ( JLD -NPs) emit fluorescence (λ em = 962 nm, Φ f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD -NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.