Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21
Jibo Han, Liming Lin, Zimin Fang, Bozhi Ye, Xue Han, Jiachen Xu, Binjiang Han, Julian Min, Jinfu Qian, Gaojun Wu, Yi Wang, Guang Liang
Abstract
Our study illustrates a cardiomyocyte-specific USP28-TRIM21 axis in regulating hypertrophic cardiomyopathy and presents USP28 as a potential target for the treatment of cardiac hypertrophy.
Topics & Concepts
Deubiquitinating enzymeUbiquitinAntioxidantCell biologyCardiac hypertrophyChemistryMuscle hypertrophyUbiquitin ligaseInternal medicineCancer researchMedicineBiologyBiochemistryGeneMitochondrial Function and PathologyUbiquitin and proteasome pathwaysATP Synthase and ATPases Research