Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C–H activation
Tsuyoshi Oyama, Lorena Mendive‐Tapia, Verity Cowell, Adelina Kopp, Marc Vendrell, Lutz Ackermann
Abstract
This manganese-catalyzed late-stage NBD peptide labeling featured excellent site- and diastereo- E -selectivity, enabling large Stokes shifts, fluorogenic NIR emission, and application for real-time imaging of live bacteria under wash free conditions.
Topics & Concepts
PeptideFluorescenceChemistryCombinatorial chemistryCatalysisSmall moleculeBiochemistryQuantum mechanicsPhysicsCatalytic C–H Functionalization MethodsClick Chemistry and ApplicationsFluorine in Organic Chemistry