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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Angelo Taglialatela, Giuseppe Leuzzi, Vincenzo Sannino, Raquel Cuella-Martin, Jen‐Wei Huang, Foon Wu-Baer, Richard Baer, Vincenzo Costanzo, Alberto Ciccia

2021Molecular Cell171 citationsDOIOpen Access PDF

Topics & Concepts

BiologyDNA damagePoly ADP ribose polymeraseHomologous recombinationPolymeraseDNA repairDNA polymeraseMutantMutationCell biologyDNADNA glycosylaseMolecular biologyGeneticsGeneDNA Repair MechanismsCRISPR and Genetic EngineeringPARP inhibition in cancer therapy
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps | Litcius