Palladium( <scp>ii</scp> ), platinum( <scp>ii</scp> ), and silver( <scp>i</scp> ) complexes with 3-acetylcoumarin benzoylhydrazone Schiff base: Synthesis, characterization, biomolecular interactions, cytotoxic activity, and computational studies
Shadia A. Elsayed, Islam M. Elnabky, Mohamed M. Aboelnga, Ahmed M. El‐Hendawy
Abstract
and selective index (SI) values indicated the higher cytotoxic activity of all the metal complexes compared to their parent ligand. Among all the compounds, the complex C2 showed the highest activity. These results confirmed the improvement of the anticancer activity of the ligand by incorporating the metal ions. In addition, flow cytometry results showed that complexes C1 and C2 induced cell cycle arrest at S and G1/S, respectively.
Topics & Concepts
ChemistrySchiff basePalladiumPlatinumBiomoleculeDocking (animal)Combinatorial chemistryStereochemistryBiochemistryCatalysisMedicineNursingMetal complexes synthesis and propertiesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds