Prevalence and Mortality of Infective Endocarditis in Community-Acquired and Healthcare-Associated <i>Staphylococcus aureus</i> Bacteremia: A Danish Nationwide Registry-Based Cohort Study
Lauge Østergaard, Marianne Voldstedlund, Niels Eske Bruun, Henning Bundgaard, Kasper Iversen, Nana Køber, Anders Dahl, Sandra Chamat‐Hedemand, Jeppe Kofoed Petersen, Andreas Dalsgaard Jensen, Jens Jørgen Christensen, Flemming Schønning Rosenvinge, Jens Otto Jarløv, Claus Moser, Christian Østergaard Andersen, John Coia, Ea Sofie Marmolin, Kirstine K. Søgaard, Lars Lemming, Lars Køber, Emil Loldrup Fosbøl
Abstract
Abstract Background Staphylococcus aureus bacteremia (SAB) can be community-acquired or healthcare-associated, and prior small studies have suggested that this mode of acquisition impacts the subsequent prevalence of infective endocarditis (IE) and patient outcomes. Methods First-time SAB was identified from 2010 to 2018 using Danish nationwide registries and categorized into community-acquired (no healthcare contact within 30 days) or healthcare-associated (SAB &gt;48 hours of hospital admission, hospitalization within 30 days, or outpatient hemodialysis). Prevalence of IE (defined from hospital codes) was compared between groups using multivariable adjusted logistic regression analysis. One-year mortality of S aureus IE (SAIE) was compared between groups using multivariable adjusted Cox proportional hazard analysis. Results We identified 5549 patients with community-acquired SAB and 7491 with healthcare-associated SAB. The prevalence of IE was 12.1% for community-acquired and 6.6% for healthcare-associated SAB. Community-acquired SAB was associated with a higher odds of IE as compared with healthcare-associated SAB (odds ratio, 2.12 [95% confidence interval {CI}, 1.86–2.41]). No difference in mortality was observed with 0–40 days of follow-up for community-acquired SAIE as compared with healthcare-associated SAIE (HR, 1.07 [95% CI, .83–1.37]), while with 41–365 days of follow-up, community-acquired SAIE was associated with a lower mortality (HR, 0.71 [95% CI, .53–.95]). Conclusions Community-acquired SAB was associated with twice the odds for IE, as compared with healthcare-associated SAB. We identified no significant difference in short-term mortality between community-acquired and healthcare-associated SAIE. Beyond 40 days of survival, community-acquired SAIE was associated with a lower mortality.