Machine-Learning Model for Prediction of Cefepime Susceptibility in Escherichia coli from Whole-Genome Sequencing Data
Romney M. Humphries, Eugene Bragin, Julian Parkhill, Grace Morales, Jonathan E. Schmitz, Paul Rhodes
Abstract
The declining cost of performing bacterial whole-genome sequencing (WGS) coupled with the availability of large libraries of sequence data for well-characterized isolates have enabled the application of machine-learning (ML) methods to the development of nonlinear sequence-based predictive models. We tested the ML-based model developed by Next Gen Diagnostics for prediction of cefepime phenotypic susceptibility results in Escherichia coli .
Topics & Concepts
CefepimeBroth microdilutionBiologyEscherichia coliWhole genome sequencingClinical microbiologyMicrobiologyAntimicrobialGenomeMinimum inhibitory concentrationGeneticsCeftazidimeBacteriaGenePseudomonas aeruginosaBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaDiphtheria, Corynebacterium, and Tetanus