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Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation

Ahra Go, Jeong Woon Jang, Woori Lee, Jae Du Ha, Hyun Jin Kim, Hye Jin Nam

2020European Journal of Medicinal Chemistry42 citationsDOI

Topics & Concepts

OlaparibTriple-negative breast cancerPARP1ChemistryPARP inhibitorCancer researchBreast cancerSynthetic lethalityCancerAutophagyOvarian cancerApoptosisPoly ADP ribose polymeraseInternal medicineBiologyBiochemistryMedicineDNA repairEnzymeGenePolymerasePARP inhibition in cancer therapyProtein Degradation and InhibitorsEndoplasmic Reticulum Stress and Disease
Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation | Litcius