Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
N. R. Jena
Abstract
The recent outbreak of COVID-19 has affected human lives severely. The human-to-human transmission of this viral disease has become deadly due to the unavailability of COVID-19 specific drugs. Here, an overview of various attempts made to design different therapeutic agents against various structural and non-structural proteins of SARS-CoV-2 has been summarized. Emphasis has been made to highlight the mechanisms of drug action and ways to design better inhibitors of these proteins. The roles of anti-oxidants and vitamins in suppressing COVID-19 are also discussed.
Topics & Concepts
DrugCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)UnavailabilityDrug action2019-20 coronavirus outbreakAction (physics)Drug discoveryVirologyOutbreakComputational biologyDiseaseBiologyMedicinePharmacologyBioinformaticsInfectious disease (medical specialty)EngineeringPhysicsReliability engineeringQuantum mechanicsPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesComputational Drug Discovery Methods