Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties – Synthesis and biological activity
Franz Steppeler, Dominika Iwan, Radosław Gaida, Marta Denel‐Bobrowska, Agnieszka B. Olejniczak, Elżbieta Wojaczyńska
Abstract
2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.
Topics & Concepts
ThioureaChemistryEbselenTriazoleOctaneCytotoxicityHeptanePotency1,2,4-TriazoleStereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryIn vitroBiochemistryEnzymeGlutathioneGlutathione peroxidaseClick Chemistry and ApplicationsSynthesis and Biological EvaluationChemical Synthesis and Analysis