Cross‐Dehydrogenative Alkynylation: A Powerful Tool for the Synthesis of Internal Alkynes
Ji‐Shu Zhang, Long Liu, Tieqiao Chen, Li‐Biao Han
Abstract
Alkynes are among the most fundamentally important organic compounds and are widely used in synthetic chemistry, biochemistry, and materials science. Thus, the development of an efficient and sustainable method for the preparation of alkynes has been a central concern in organic synthesis. Cross-dehydrogenative coupling utilizing E-H and Z-H bonds in two different molecules can avoid the need for prefunctionalization of starting materials and has become one of the most straightforward methods for the construction of E-Z chemical bonds. This Review summarizes recent progress in the preparation of internal alkynes by cross-dehydrogenative coupling with terminal alkynes.
Topics & Concepts
AlkynylationOrganic synthesisCombinatorial chemistryChemistryMoleculeGreen chemistryOrganic moleculesChemical synthesisNanotechnologyOrganic chemistryCatalysisMaterials scienceSupramolecular chemistryIn vitroBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques