CeO<sub>2</sub>@NH<sub>2</sub> functionalized electrodes for the rapid detection of SARS-CoV-2 spike receptor binding domain
Ayu Triastuti, Salma Nur Zakiyyah, Shabarni Gaffar, Isa Anshori, Akhmadi Surawijaya, Darmawan Hidayat, Hesti Lina Wiraswati, Muhammad Yusuf, Yeni Wahyuni Hartati
Abstract
. This aptasensor was used to detect salivary and oropharyngeal swab samples of normal individuals with the addition of Spike RBD, and the recoveries were 92.96% and 96.52%, respectively. The testing on nasopharyngeal swab samples of COVID-19 patients showed that the aptasensor results were comparable with the qRT-PCR results. Thus, the developed aptasensor has the potential to be applied as a SARS-CoV-2 rapid test method for clinical samples.
Topics & Concepts
Spike ProteinSpike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)ElectrodeDomain (mathematical analysis)ReceptorChemistryMedicineComputer scienceBiochemistryMathematicsPhysical chemistryInternal medicineMathematical analysisDiseaseInfectious disease (medical specialty)Software engineeringAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testingBiosensors and Analytical Detection