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ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage

Elodie Bournique, Ambrocio Sanchez, Sunwoo Oh, Daniel Ghazarian, Alisa L. Mahieu, Lavanya Manjunath, Eirene Marie Q. Ednacot, Pedro Ortega, Selma Masri, Ivan Marazzi, Rémi Buisson

2025Nature Structural & Molecular Biology12 citationsDOIOpen Access PDF

Topics & Concepts

DNA damageTranscription factorCell biologyInnate immune systemBiologyTranscription (linguistics)NF-κBGeneDNAGene expressionSignal transductionImmune systemGeneticsPhilosophyLinguisticsNF-κB Signaling PathwaysDNA Repair Mechanismsinterferon and immune responses
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage | Litcius