The functions and networks of non-coding RNAs in the pathogenesis of Rheumatoid Arthritis
Jia‐Bao Liu, Shan Song, Rong Zhao, Heyi Zhang, Sheng‐Xiao Zhang
Abstract
Rheumatoid Arthritis (RA) is a chronic autoimmune disease. Its main feature is inflammation of synovial tissue with irreversible joint damage and severe physical damage. Non-coding RNAs (ncRNAs) are a class of RNAs that do not have the ability to encode proteins but are vital regulators that mediate many fundamental cellular processes and play an essential role in the pathogenesis of RA. Multiple verified ncRNAs have been confirmed as a prospective biomarkers for diagnosing and treating RA. In this paper, we aim to sort out the role of ncRNAs in the pathogenesis of RA and provide new ideas for the diagnosis and treatment of RA.
Topics & Concepts
PathogenesisRheumatoid arthritisInflammationImmunologyArthritisMedicineDiseaseAutoimmune diseaseBioinformaticsComputational biologyBiologyPathologyCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation