The Central Role of mTORC1 in Amino Acid Sensing
Shusheng Yue, Guanya Li, Shanping He, Tingting Li
Abstract
The mTOR is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have emphasized the importance of lysosomes as a hub for nutrient sensing, especially amino acid sensing by mTORC1. This review highlights recent advances in understanding the amino acid-mTORC1 signaling axis and the role of mTORC1 in cancer.
Topics & Concepts
mTORC1Nutrient sensingRegulatorAmino acidPI3K/AKT/mTOR pathwayMaster regulatorCell biologyBiologyCell growthSignal transductionBiochemistryGeneTranscription factorPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsHedgehog Signaling Pathway Studies