Cyclosporin Structure and Permeability: From A to Z and Beyond
Karen Corbett, Leigh Ford, Dallas B. Warren, Colin W. Pouton, David K. Chalmers
Abstract
Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and potential pharmaceutical applications. Several members of the cyclosporin compound family have remarkably high passive membrane permeabilities that are not well-described by simple structural metrics. Here we review experimental studies of cyclosporin structure and permeability, including cyclosporin-metal complexes. We also discuss models for the conformation-dependent permeability of cyclosporins and similar compounds. Finally, we identify current knowledge gaps in the literature and provide recommendations regarding future avenues of exploration.
Topics & Concepts
CyclosporinsChemistryMembrane permeabilityPermeability (electromagnetism)Combinatorial chemistryMembraneBiophysicsBiochemistryInternal medicineMedicineBiologyTransplantationRNA Interference and Gene DeliverySignaling Pathways in DiseaseChemical Synthesis and Analysis