Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction
Nga Thi Thanh Nguyen, Sang Yoon Lee
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumProtein kinase BReactive oxygen speciesCancer researchChemistryPI3K/AKT/mTOR pathwayOxidative stressProgrammed cell deathCancer cellSulindacApoptosisBiologyPharmacologyCancerBiochemistryInternal medicineMedicineNonsteroidalAdenosine and Purinergic SignalingPeptidase Inhibition and AnalysisPI3K/AKT/mTOR signaling in cancer