Visible-light-promoted defluorinated alkylation of trifluoromethyl alkenes initiated by radical [1,2]-Brook rearrangement: facile synthesis of<i>gem</i>-difluoro homoallylic alcohol derivatives
Tao Qin, Chunlu Xu, Ge Zhang, Qian Zhang
Abstract
A photoinduced radical [1,2]-Brook rearrangement/defluorinated alkylation reaction of α-trifluoromethyl alkenes with α-silyl alcohols was developed for facile access to gem -difluoro homoallylic alcohol derivatives.
Topics & Concepts
ChemistryTrifluoromethylAlkylationAlcoholAllyl alcoholMedicinal chemistrySilylationOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryRadical Photochemical Reactions