Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab
Peter Bults, Anna van der Voort, Coby Meijer, Gabe S. Sonke, Rainer Bischoff, Nico C. van de Merbel
Topics & Concepts
DeamidationTrastuzumabPertuzumabChemistryIn vivoAsparaginePharmacologyChromatographyIn vitroBiochemistryMonoclonal antibodyAntibodyMonoclonalResidue (chemistry)Plasma protein bindingImmunoglobulin light chainMass spectrometryAntibody-dependent cell-mediated cytotoxicityBiological activityHER2/EGFR in Cancer ResearchProtein purification and stabilityPeptidase Inhibition and Analysis