Pd-Catalyzed Regio- and Enantioselective Aminoarylation of Allenols with Aryl Iodides and 2-Pyridones
Hongfang Li, Ijaz Khan, Meiqi Li, Zheng Wang, Xue Wu, Kuiling Ding, Yong Jian Zhang
Abstract
A new asymmetric catalytic protocol for the synthesis of enantioenriched N-allyl 2-pyrodones has been developed via the first Pd-catalyzed regio- and enantioselective aminoarylation of allenols with aryl iodides and 2-pyridones. By using a palladium complex generated in situ from Pd2(dba)3·CHCl3 and (S,S,S)-SKP as a catalyst, the three-component aminoarylation proceeded smoothly to afford a variety of functionalized N-allylic 2-pyridones in high yields with good regioselectivities and excellent enantioselectivities.
Topics & Concepts
Enantioselective synthesisChemistryAllylic rearrangementCatalysisArylPalladiumCombinatorial chemistryRegioselectivityOrganic chemistryMedicinal chemistryAlkylCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods