XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson
Abstract
(Cell Reports 43, 113600; February 27, 2024) In the version of this article that was originally published on January 22, 2024, one of the genes shown in Figure 3A was mislabeled by accident. Specifically, the gene labeled “CMTR2” should have been labeled “CMPK2” instead. The original Figure 3A has since been replaced with a corrected version, and both the original and corrected versions appear below for the reader’s reference. This error and the correction thereof do not impact the conclusions of this paper. The authors regret this error. XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cellsZou et al.Cell ReportsJanuary 22, 2024In BriefZou et al. identify a requirement for the XRN1 exoribonuclease in human cancer cell lines with high expression of interferon-stimulated genes. XRN1 depletion causes accumulation of complementary sense/anti-sense transcript pairs and cell-intrinsic activation of the interferon-inducible double-stranded RNA sensor protein kinase R, leading to cancer cell lethality. Full-Text PDF Open Access