An environmentally benign way to synthesize 2-thiocyano-1,3-dicarbonyl compounds with high antifungal activity: a key role of solvent
Andrey S. Kirillov, Egor A. Semenov, Oleg V. Bityukov, М. А. Кузнецова, V.N. Demidova, А. Н. Рогожин, Alexei P. Glinushkin, Vera A. Vil’, Alexander O. Terent’ev
Abstract
from the thiocyanate anion, followed by the addition of thiocyanogen to the double bond of the enol tautomer of 1,3-dicarbonyl compounds, which finally gives the products. A variety of thiocyanated 1,3-dicarbonyl compounds bearing different functional groups were obtained in 37-82% yields and were shown to exhibit high antifungal activity.
Topics & Concepts
ChemistryAntifungalKey (lock)Combinatorial chemistrySolventEnvironmentally friendlyOrganic chemistryMicrobiologyComputer scienceEcologyBiologyComputer securitySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions