Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion
Jurriën W. Collet, Bénédicte Morel, Hung-Chien Lin, Thomas R. Roose, Pieter Mampuys, Romano V. A. Orrù, Eelco Ruijter, Bert U. W. Maes
Abstract
-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.
Topics & Concepts
ChemistryIsocyanideYield (engineering)NickelAminationSolventCatalysisCombinatorial chemistryUracilOrganic chemistryDNAMetallurgyMaterials scienceBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Reactions