Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer
Xunian Zhou, Paul Kurywchak, Kerri Wolf-Dennen, Sara P.Y., Dinanath Sulakhe, Mark D’Souza, Bingqing Xie, Natalia Maltsev, T. Conrad Gilliam, Chia-Chin Wu, Kathleen M. McAndrews, Valerie S. LeBleu, David J. McConkey, Olga V. Volpert, Shanna Pretzsch, Bogdan Czerniak, Colin P. Dinney, Raghu Kalluri
Abstract
gene. Gene network analyses revealed that exoDNA is associated with cancer, inflammation, and immunity in BC exosomes. Our findings show utility of exoDNA as an objective, non-invasive strategy to identify novel biomarkers and targets for BC.
Topics & Concepts
Liquid biopsyBladder cancerUrineMicrovesiclesSomatic cellGeneCancermicroRNACystoscopyBiologyGenomeBiomarkerMedicineCancer researchUrinary systemGeneticsInternal medicineBladder and Urothelial Cancer TreatmentsExtracellular vesicles in diseaseUrinary and Genital Oncology Studies